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Edward R. Dougherty Biomarker development: Prudence, risk, and reproducibility BioEssays 34

Version of Record online: 15 FEB 2012 | DOI: 10.1002/bies.201200003

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Is a two-fold approach — preliminary studies based on small samples followed by a large-sample study to check reproducibility — in the search for biomarkers really prudent?

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