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Bastiaan Star and Sissel Jentoft Why does the immune system of Atlantic cod lack MHC II? BioEssays 34

Version of Record online: 13 APR 2012 | DOI: 10.1002/bies.201200005

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MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain this loss. The lack of MHC II coincides with an increased number of genes for MHC I and Toll-like receptors (TLRs).

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