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Eric M. Kofoed and Russell E. Vance NAIPs: Building an innate immune barrier against bacterial pathogens BioEssays 34

Version of Record online: 19 APR 2012 | DOI: 10.1002/bies.201200013

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The NAIP-NLRC4 inflammasomes appear to function as receptors for specific bacterial molecules, but it remains unclear how NAIPs (NLR family, apoptosis inhibitory proteins) recognize and distinguish ligands, and what role NLRC4 (NLR family, CARD domain-containing 4) plays in ligand recognition, but it probably serves as an adaptor for caspase-1.

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