Thomas B. L. Kirkwood and Axel Kowald The free-radical theory of ageing – older, wiser and still alive BioEssays 34
The free-radical theory is more complex than commonly recognized. Spatial effects need to be considered; e.g. mitochondrial DNA, a main target of ROS, is attached to the inner mitochondrial membrane, where most radicals are produced. This influences the likely effectiveness of antioxidants (AOx) and of turnover processes to control cellular damage.
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