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Xosé R. Bustelo Intratumoral stages of metastatic cells: A synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more BioEssays 34

Version of Record online: 18 JUN 2012 | DOI: 10.1002/bies.201200041

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We summarize recent data about the origin of metastatic traits, the routes that regulate the intratumoral migration and subsequent dissemination of metastatic cancer cells outside the primary tumor mass, and the tumor extrinsic and intrinsic mechanisms that favor metastasis development. The therapeutic implications of this new information are also discussed.

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