Monireh Dashti, Maikel P. Peppelenbosch and Farhad Rezaee Hedgehog signalling as an antagonist of ageing and its associated diseases BioEssays 34
Hedgehog is a morphogenic signal during embryogenesis and adult life with many vital biological functions such as neuromodulators and anti-adipogenesis. Downregulation of Hedgehog signalling is associated with ageing-related diseases like Alzheimer/Parkinson and T2D diseases and upregulation of this signalling reduces risk of these diseases. Thus, Hedgehog signalling is antagonist of ageing.
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