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Leif E. Sander Improved vaccines through targeted manipulation of the body's immunological risk-assessment? BioEssays 34

Article first published online: 20 JUL 2012 | DOI: 10.1002/bies.201200057

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Microbial threat levels physiologically correlate with the robustness of resulting immune responses (blue line). Threat evaluation could be harnessed to skew this correlation (red line) to improve vaccine efficiency. equation image low threat stimulus (e.g., dead microbes), equation image high threat stimulus (e.g., viable microbes), and equation image modified low threat stimulus (e.g., killed microbes + vita-PAMPs).

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