Leif E. Sander Improved vaccines through targeted manipulation of the body's immunological risk-assessment? BioEssays 34
Version of Record online: 20 JUL 2012 | DOI: 10.1002/bies.201200057
Microbial threat levels physiologically correlate with the robustness of resulting immune responses (blue line). Threat evaluation could be harnessed to skew this correlation (red line) to improve vaccine efficiency. low threat stimulus (e.g., dead microbes), high threat stimulus (e.g., viable microbes), and modified low threat stimulus (e.g., killed microbes + vita-PAMPs).
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