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Maho Shibata and Michael M. Shen The roots of cancer: Stem cells and the basis for tumor heterogeneity BioEssays 35

Article first published online: 2 OCT 2012 | DOI: 10.1002/bies.201200101

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Concepts from stem cell biology can explain the basis for intertumoral heterogeneity between different tumors of the same tissue type, as well as intratumoral heterogeneity within a single tumor. In this review, we discuss the cell of origin, cancer stem cells, and clonal evolution, with a focus on prostate cancer.

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