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Rahul K. Das, Anuradha Mittal and Rohit V. Pappu How is functional specificity achieved through disordered regions of proteins? BioEssays 35

Article first published online: 9 NOV 2012 | DOI: 10.1002/bies.201200115

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N-terminal disordered regions control inactivation of potassium channels. The mechanism of inactivation is different for BK channel versus Shaker channels. The former populates an O* state that shows intermediate activity. Adaptation of existing phenomenological models for coupled folding and binding explains channel-specific differences in N-type inactivation through disordered regions.

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