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Francesco Catania and Michael Lynch A simple model to explain evolutionary trends of eukaryotic gene architecture and expression BioEssays 35

Version of Record online: 9 APR 2013 | DOI: 10.1002/bies.201200127

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We propose a scenario wherein factors that regulate pre-mRNA splicing and 3′-end formation compete for access to binding sites within introns and 3′ UTRs. Dynamic molecular tradeoffs determine the outcome of these antagonistic interactions and mediate the selection of exons and transcription termination sites.

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