Laura E. Swan Initiation of clathrin-mediated endocytosis: All you need is two? BioEssays 35
Coccuci et al. propose that clathrin coated pits (ccps) randomly nucleate via simultaneous arrival of two AP2 complexes and a clathrin triskelion at the plasma membrane. The nascent ccp stabilizes by incorporating more clathrin/AP2 complexes and early factors such as FCHo1/2, before integrating transmembrane cargoes and acquiring curvature.
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