Hugo Bowne-Anderson, Marija Zanic, Monika Kauer and Jonathon Howard Microtubule dynamic instability: A new model with coupled GTP hydrolysis and multistep catastrophe BioEssays 35
The mechanisms underlying microtubule dynamic instability are not well understood. We review the existing theoretical models, from single-protofilament to multiple-protofilament kinetic models utilizing a variety of hydrolysis mechanisms. We provide a novel model utilizing a coupled GTP hydrolysis mechanism, accounting for many experimental observations, including the multistep nature of catastrophe.
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