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Keiko Akagi, Jingfeng Li and David E. Symer How do mammalian transposons induce genetic variation? A conceptual framework BioEssays 35

Version of Record online: 14 JAN 2013 | DOI: 10.1002/bies.201200133

Thumbnail image of graphical abstract

Wide-ranging genetic variation caused by mammalian transposable elements. Schematics depict a mobile genetic element polymorphism in a genomic target site (top, YFG, your favorite gene); somatic mobilization in normal development or during cancer formation (middle, dark circles); and variable impacts of germline vs. somatic insertions accumulated over evolutionary time (bottom).

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