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Ben Zhang, Roman Krawetz and Derrick E. Rancourt Would the real human embryonic stem cell please stand up? BioEssays 35

Version of Record online: 7 MAY 2013 | DOI: 10.1002/bies.201200162

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Human and mouse embryonic stem cells (ESCs) are pluripotent and can give rise to any adult cell type. hESCs are classified as “primed” and one step differentiated from their “naïve” mESC counterpart. We review the strategies used to generate pluripotent cells and discuss the elusive derivation of naïve human ESCs.

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