E-mail

E-mail a Wiley Online Library Link

Laura Regué, Fan Mou and Joseph Avruch G protein-coupled receptors engage the mammalian Hippo pathway through F-actin BioEssays 35

Article first published online: 1 MAR 2013 | DOI: 10.1002/bies.201200163

Thumbnail image of graphical abstract

The hippo pathway, a protein kinase cascade activated by cell contact, phosphorylates the YAP oncogene to inhibit proliferation. GPCRs like PAR1 that recruit Gα12/13 and activate RhoA can dephosphorylate and activate YAP through an inhibition of the hippo pathway. This requires F-actin assembly, which also activates YAP through hippo-independent mechanisms.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH