Laura Regué, Fan Mou and Joseph Avruch G protein-coupled receptors engage the mammalian Hippo pathway through F-actin BioEssays 35
The hippo pathway, a protein kinase cascade activated by cell contact, phosphorylates the YAP oncogene to inhibit proliferation. GPCRs like PAR1 that recruit Gα12/13 and activate RhoA can dephosphorylate and activate YAP through an inhibition of the hippo pathway. This requires F-actin assembly, which also activates YAP through hippo-independent mechanisms.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf