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Laura Regué, Fan Mou and Joseph Avruch G protein-coupled receptors engage the mammalian Hippo pathway through F-actin BioEssays 35

Article first published online: 1 MAR 2013 | DOI: 10.1002/bies.201200163

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The hippo pathway, a protein kinase cascade activated by cell contact, phosphorylates the YAP oncogene to inhibit proliferation. GPCRs like PAR1 that recruit Gα12/13 and activate RhoA can dephosphorylate and activate YAP through an inhibition of the hippo pathway. This requires F-actin assembly, which also activates YAP through hippo-independent mechanisms.

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