Jingwei Xie, Christophe Erneux and Isabelle Pirson How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? BioEssays 35
PtdIns(3,4)P2 (a SHIP1/2 product) is involved in cellular adhesion, migration, and cytoskeletal organization. SHIP2 docking properties, besides its 5-phosphatase activity, help in its recruitment to subcellular compartments where PtdIns(3,4)P2 is then produced. We discuss the involvement of SHIP2 (as a phosphatase* or a scaffold protein) in cytoskeletal dynamics and receptors endocytosis.
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