Spyros Petrakis, Martin H. Schaefer, Erich E. Wanker and Miguel A. Andrade-Navarro Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners BioEssays 35
Toxic polyQ proteins form beta-sheet aggregates (A). A partner with a coiled-coil (CC) conformation interacting with the toxic protein at its polyQ domain, enhances aggregation (B). On the contrary, a non-CC partner that interacts with the toxic protein at a different domain than its polyQ, suppresses protein aggregation (B).
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