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Ann M. Morgan, Jennifer Lo and David E. Fisher How does pheomelanin synthesis contribute to melanomagenesis? BioEssays 35

Article first published online: 7 MAY 2013 | DOI: 10.1002/bies.201300020

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Pheomelanin synthesis is associated with melanoma formation, but the mechanism has not been fully elucidated. We hypothesize that pheomelanin promotes formation of genotoxic reactive oxygen species, and/or that pheomelanin synthesis consumes cellular glutathione stores.

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