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Orkun S. Soyer and Maureen A. O'Malley Evolutionary systems biology: What it is and why it matters BioEssays 35

Version of Record online: 16 MAY 2013 | DOI: 10.1002/bies.201300029

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Evolutionary systems biology (ESB) generates multilevel mechanistic and evolutionary understanding of genotype-phenotype relationships. By combining mathematical, molecular, and cellular approaches to evolution, ESB generalizes network knowledge across species, predicts mutational effects, and defines the core network structures and dynamics that have evolved to cause intracellular and intercellular responses.

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