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Carmela Matrone A new molecular explanation for age-related neurodegeneration: The Tyr682 residue of amyloid precursor protein BioEssays 35

Version of Record online: 14 AUG 2013 | DOI: 10.1002/bies.201300041

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Mutation of Tyr682 on the YENPTY domain of APP affects APP binding to adaptor proteins and induces an alteration in its trafficking within neurons. These events in turn impact on cognitive and learning performance, which are symptoms of aging and neuronal defects.

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