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Gareth M. Thomas and Takashi Hayashi Smarter neuronal signaling complexes from existing components: How regulatory modifications were acquired during animal evolution BioEssays 35

Version of Record online: 14 AUG 2013 | DOI: 10.1002/bies.201300076

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In nervous systems of organisms with higher brain function, smarter neuronal signaling complexes have arisen from primitive AMPA-type glutamate receptor components through evolutionary acquisition of post-translational palmitoylation sites and PDZ-binding motifs. These additional regulatory modifications may allow more precise control of protein localization and activity to support higher brain functions.

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