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Nicole Edgar and Colleen A. McClung Major depressive disorder: A loss of circadian synchrony? BioEssays 35

Article first published online: 3 SEP 2013 | DOI: 10.1002/bies.201300086

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Li and colleagues organized microarray data from human post-mortem brain tissue in a pseudo-time series to examine molecular rhythms. They revealed that healthy subjects have strong diurnal gene expression patterns in several brain regions outside the SCN, and these patterns are significantly disrupted in subjects with major depressive disorder.

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