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John M. Sedivy, Jill A. Kreiling, Nicola Neretti, Marco De Cecco, Steven W. Criscione, Jeffrey W. Hofmann, Xiaoai Zhao, Takahiro Ito and Abigail L. Peterson Death by transposition – the enemy within? BioEssays 35

Version of Record online: 15 OCT 2013 | DOI: 10.1002/bies.201300097

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Transposable elements are autonomous DNA parasites that are largely deleterious to their host genomes. Cells use multiple mechanisms to silence them but activation is increasingly being found in somatic tissues. Surveillance can break down with aging, and genome destabilization caused by active transposition may be an important molecular aging process.

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