Rohan A. Patil, Martin E. Kolewe, Jennifer Normanly, Elsbeth L. Walker and Dr. Susan C. Roberts Contribution of taxane biosynthetic pathway gene expression to observed variability in paclitaxel accumulation in Taxus suspension cultures Biotechnology Journal 7
Paclitaxel is a chemotherapeutic agent used for the treatment of several cancer types. Although plant cells cultures have variable productivity, it has nevertheless become a sustainable source of paclitaxel supply. In this article, the authors correlate gene expression levels to accumulation of the compound – it is the first study to compare gene expression in cultures with variable levels of paclitaxel accumulation, providing valuable information regarding the regulation of paclitaxel synthesis.
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