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Olga Shebanova and Dr. Daniel A. Hammer Biochemical and mechanical extracellular matrix properties dictate mammary epithelial cell motility and assembly Biotechnology Journal 7

Version of Record online: 16 DEC 2011 | DOI: 10.1002/biot.201100188

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Understanding cell migration and cell-cell interactions are key to understanding cell invasion, a critical step in the progression of breast cancer. In this study, the authors show that the migration velocity and the assembly of breast cancer epithelial cells is optimal at intermediate concentrations of fibronectin concentration and substrate compliance. On low compliance polyacrylamide gels (400 Pa), cells assemble into clusters, whereas on stiffer gels, cells remain dispersed.

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