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Lydia M. Contreras-Martinez, Jason T. Boock, Jan S. Kostecki and Prof. Matthew P. DeLisa The ribosomal exit tunnel as a target for optimizing protein expression in Escherichia coli Biotechnology Journal 7

Article first published online: 2 MAR 2012 | DOI: 10.1002/biot.201100198

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Production of recombinant proteins has broad implications in various disciplines, including biotechnology and biopharmaceuticals. The current study provides support for the notion that the ribosomal exit tunnel is not simply a static conduit for newly made proteins but rather a dynamic channel that is intimately involved in the production of cellular proteins. The improved knowledge of how exit tunnel proteins contribute to protein expression and folding could be key in the context of rationally engineering bacterial translation for efficient production of active, structurally complex proteins.

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