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Donatella Cimini, Mario De Rosa and Prof. Chiara Schiraldi Production of glucuronic acid-based polysaccharides by microbial fermentation for biomedical applications Biotechnology Journal 7

Version of Record online: 29 NOV 2011 | DOI: 10.1002/biot.201100242

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A safer alternative to animal tissue extraction or chemical synthesis of biomedically relevant polymers is the development of biotech processes that exploit capsular/extracellular polysaccharide-producing microorganisms. This review provides an overview on recent advances in the development of molecular tools and fermentation technologies that lead to a better understanding of the metabolic mechanisms and required process conditions for microbial production of four glucuronic acid-based polymers (HA, CS, heparin, alginate).

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