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Jonathan Meade, Saleem Khan, Mohammad Ataai and Michael Domach Use of flux pre-analysis to enable 13C tracer studies in pyruvate kinase-deficient Escherichia coli Biotechnology Journal 7

Article first published online: 2 MAR 2012 | DOI: 10.1002/biot.201100338

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Pyruvate kinase-deficient Escherichia coli (PB25) is a low by-product producing yet fast growing strain that has been shown to have technological potential. Flux bounding through finding the extreme point flux sets was previously reported to identify highly variable fluxes and thus alternate metabolite trafficking scenarios. In this study, the authors examine the utility of bounding the fluxes and predetermine the trafficking scenarios in the PB25 problem.

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