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Mathias Bernhardt, Marta Galach, Daniel Novak and Dr. Jochen Utikal Mediators of induced pluripotency and their role in cancer cells – current scientific knowledge and future perspectives Biotechnology Journal 7

Version of Record online: 16 MAY 2012 | DOI: 10.1002/biot.201100347

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Reprogramming of somatic cells and tumorigenesis is driven by similar mechanisms: The process of reprogramming somatic cells into induced pluripotent stem cells (iPSCs) is mediated by tumor suppressor genes and driven by transcription factors that are involved in tumorigenesis. The generation of induced pluripotent cancer cells (iPCCs) from cancer cells can provide a tool to simulate tumor development and to identify novel therapeutic targets for cancer treatment. This review gives an overview of the common features of pluripotent stem cells and cancer cells.

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