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Van Thanh Hoang, Abraham Zepeda-Moreno and Prof. Anthony D. Ho Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance Biotechnology Journal 7

Version of Record online: 16 MAY 2012 | DOI: 10.1002/biot.201100350

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Similar to normal hematopoietic stem cells (HSC), leukemic stem cells (LSC) that reside within the niches divide very slowly and hence, are resistant against conventional anti-proliferating drugs. Upon chemotherapy, although the bulk of leukemic cells are killed, some LSC survive and are able to repopulate resulting in relapse. Disrupting adhesion of LSC to the niche or targeting their protective microenvironment may represent alternative pathways to render LSC vulnerable to chemotherapy or immune modulation such as allogeneic HSC transplantation.

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