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Dr. Karol M. Łącki High-throughput process development of chromatography steps: Advantages and limitations of different formats used Biotechnology Journal 7

Version of Record online: 25 JUL 2012 | DOI: 10.1002/biot.201100475

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Intrinsic features of formats used in high-throughput process development (HTPD) studies of chromatography steps can influence results. Theoretical analysis of the mass transfer rate limiting step during adsorption of proteins on different types of chromatography resins reveal that effects related to different hydrodynamic conditions occurring when different HTPD formats are used can lead to systematic deviation from results obtained at relevant scale. These effects can be minimized by choosing a right format for the screening studies based on a the proposed high throughput format maps.

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