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Harish Chandran, Abhijit Rangnekar, Geetha Shetty, Erik A. Schultes, John H. Reif and Prof. Thomas H. LaBean An autonomously self-assembling dendritic DNA nanostructure for target DNA detection Biotechnology Journal 8

Article first published online: 10 OCT 2012 | DOI: 10.1002/biot.201100499

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Responsive and programmable DNA nanostructures have shown great promise as chemical detection systems. In this study, the authors describe a DNA detection system by using a metastable mixture of DNA hairpins (α and β) to detect the target DNA strand (T1). The target binds to and opens the first hairpin which then exponentially binds and opens the other hairpins, thus triggering a dendrimer formation. The system was further tested with HIV and Chlamydia trachomatis pathogens with positive results. This method offers an inexpensive and convenient method for detecting pathogenic DNA.

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