Dr. Tatsuya Murakami Phospholipid nanodisc engineering for drug delivery systems Biotechnology Journal 7
Mesoscale nanoparticles are attractive tools for drug delivery. To achieve biocompatibility, these particles are often coated with PEG, which can have problems with antigenicity and cellular update. HDL-like phospholipid nanodiscs generated in vitro are evolving as new and promising biocompatible drug carriers as they are very close to natural HDL and can be adjusted as needed through a wide variety of genetic and chemical modifications. This review provides a succinct overview of the use of synthetic HDL-like phospholipid nanodiscs as biocompatible drug carriers.
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