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Pierre E. Rouvière, Jing Li, Donald J. Brill, Lisa D. Reiss, Timothy R. Schwartz, Lisa A. Butterick, Stephen R. Fahnestock and Dr. Tanja Gruber Bionanotechnology application of polypeptides in a hair color product: Self-assembly enables expression, processing, and functionality Biotechnology Journal 8

Version of Record online: 1 AUG 2012 | DOI: 10.1002/biot.201200008

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It remains a major challenge to develop bionanotechnology applications for industrial-scale production, in large part due to issues of scale-up feasibility and cost of production of the materials. In this article, the authors design a system to anchor particles, e.g. pigments, onto hair via a multifunctional polypeptide that is able to self-assemble into higher order structures. At the same time they incorporate characteristics that allow efficient production in E. coli. Co-engineering of production, system assembly and system functionality of the biological material leads to high performance, while at the same time being cost-effective and scalable.

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