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Dominic J. Glover, Lars Giger, Jihyun R. Kim and Prof. Douglas S. Clark Engineering protein filaments with enhanced thermostability for nanomaterials Biotechnology Journal 8

Article first published online: 29 NOV 2012 | DOI: 10.1002/biot.201200009

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Self-assembling protein templates have enormous potential as biomaterials for the fabrication of multifunctional nanostructures that require precise positioning of individual molecules in regular patterns over large surface areas. Furthermore, the development of ultrastable protein templates will expand processing conditions and end-use applications for biomaterials that require exceptional robustness. In this article, the authors characterize the high thermal stability of a filamentous protein template, the γ-prefoldin, and subsequently use rational design to further enhance the filament's thermal stability for application as a biotemplate in the creation of platinum nanowires.

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