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Mark J. Pearson, Siavash Khazaipoul, Asta Optun, Ian F. Pryme, Beate Stern and Dr. John E. Hesketh Albumin 3′untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells Biotechnology Journal 7

Version of Record online: 29 JUN 2012 | DOI: 10.1002/biot.201200044

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Chinese hamster ovary (CHO) cells are a valuable tool and are widely used for recombinant protein production in the pharmaceutical industry; however, there remains a need to improve the recombinant protein expression levels. In this study, authors test the effectiveness of various 3′untranslated regions (UTRs) in promoting production of a naturally secreted luciferase. They show that manipulation of expression vectors by inclusion of appropriate 3′UTR sequences is a potentially useful approach to improve recombinant protein expression and yield.

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