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Dr. Rahul Godawat, Kevin Brower, Sujit Jain, Konstantin Konstantinov, Frank Riske and Veena Warikoo Periodic counter-current chromatography – design and operational considerations for integrated and continuous purification of proteins Biotechnology Journal 7

Article first published online: 9 NOV 2012 | DOI: 10.1002/biot.201200068

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Designing integrated and continuous purification and its advantages. This study demonstrates a practical, theoretical approach for the design of a continuous chromatography step using periodic counter current chromatography. A generic approach is developed based on the protein breakthrough curve and can be applied to most protein-chromatographic resin systems. The integrated and continuous mode of operation simultaneously achieves increased throughput and improved resin capacity utilization, typically unattainable in traditional batch processing.

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