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Saliha D. Durmuş Tekir and Prof. Kutlu Ö. Ülgen Systems biology of pathogen-host interaction: Networks of protein-protein interaction within pathogens and pathogen-human interactions in the post-genomic era Biotechnology Journal 8

Article first published online: 29 NOV 2012 | DOI: 10.1002/biot.201200110

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Pathogen-host interactions (PHIs): Infectious microorganisms (pathogens) communicate with human cells through interactions with human proteins on the cell's surface as well as intracellular proteins. These interactions allow the microorganisms to enter the host cell and to manipulate cellular mechanisms in order to use the host cell's capabilities to their own advantage, resulting in infection in the host organism. This article reviews these networks, which may enable us to better elaborate the mechanisms of infection and to identify improved strategies to prevent or cure infectious diseases.

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