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Jong Hwan Sung, Daehoon Han and Prof. Jong Bum Lee Self-assembled DNA-based giant thrombin nanoparticles for controlled release Biotechnology Journal 8

Version of Record online: 7 JAN 2013 | DOI: 10.1002/biot.201200312

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Giant thrombin nanoparticle for efficient thrombin delivery: in this study, the authors report a novel method for thrombin delivery by forming giant thrombin nanoparticles based on DNA nanostructures. Through strong binding between thrombins and multivalent aptamers on DNA nanostructures, giant thrombin nanoparticles were generated. These nanoparticles can perform controlled release of thrombins by introducing complementary DNA.

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