Kifah Shahin and Pauline M. Doran Tissue engineering of cartilage using a mechanobioreactor exerting simultaneous mechanical shear and compression to simulate the rolling action of articular joints Biotechnology and Bioengineering 109
A novel mechanobioreactor was used to apply simultaneous dynamic mechanical shear and compression during synthesis of human tissue-engineered cartilage in a mixed fluid environment. A treatment regime of 10 min loading per day improved the quality of the tissues substantially compared with control cultures. Synthesis of both major structural components of cartilage, glycosaminoglycan and collagen type II, was enhanced by up to an order of magnitude depending on the scaffold type and seeding cell density.
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