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Hanno Richter, Nasib Qureshi, Sebastian Heger, Bruce Dien, Michael A. Cotta and Largus T. Angenent Prolonged conversion of n-butyrate to n-butanol with Clostridium saccharoperbutylacetonicum in a two-stage continuous culture with in-situ product removal Biotechnology and Bioengineering 109

Version of Record online: 7 DEC 2011 | DOI: 10.1002/bit.24380

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This study illustrates that efficient conversion of n-butyrate into n-butanol by solventogenic Clostridium species is feasible in a continuous system operating for longer than one month. However, a relatively large amount of glucose is required to supply electrons and ATP for this conversion and for cell growth in continuous culture.

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