David W. Hammers, Apurva Sarathy, Chantal B. Pham, Charles T. Drinnan, Roger P. Farrar and Laura J. Suggs Controlled release of IGF-I from a biodegradable matrix improves functional recovery of skeletal muscle from ischemia/reperfusion Biotechnology and Bioengineering 109
Polyethylene glycol (PEG)-ylated fibrin gel (PEG-Fib) is a biodegradable matrix capable of releasing covalently-bound growth factors in a controlled manner. In this study, IGF-I conjugated PEG-Fib (PEG-Fib-IGF) was evaluated as a therapeutic approach for the treatment of skeletal muscle ischemia/reperfusion (I/R) injury. The authors found that PEG-Fib-IGF greatly improves both the histological and functional recovery of skeletal muscle from I/R, and that this improvement is likely due to increased survival of affected muscle tissue.
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