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Marketa Hnilova, Banu Taktak Karaca, James Park, Carol Jia, Brandon R. Wilson, Mehmet Sarikaya and Candan Tamerler Fabrication of hierarchical hybrid structures using bio-enabled layer-by-layer self-assembly Biotechnology and Bioengineering 109

Version of Record online: 26 DEC 2011 | DOI: 10.1002/bit.24405

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This study demonstrates a bio-enabled layer-by-layer self assembly technique utilizing a specific gold-binding peptide tag. The authors produced spatially and hierarchically controlled fusion protein multi-layered assemblies on gold nanoparticle arrays with high molecular packing density and pattering efficiency in simple, reproducible steps. This model system constitutes novel biofabrication routes to various protein arrays, plasmon-active nanometallic assemblies and devices with controlled organization, density and architecture.

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