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N.E. Timmins, M. Kiel, M. Günther, C. Heazlewood, M.R. Doran, G. Brooke and K. Atkinson Closed system isolation and scalable expansion of human placental mesenchymal stem cells Biotechnology and Bioengineering 109

Version of Record online: 17 JAN 2012 | DOI: 10.1002/bit.24425

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Timmins and coworkers describe the initial development of a closed process for bulk isolation of MSC from human placenta, and subsequent cultivation on microcarriers in scalable single-use bioreactor systems. Based on their initial data, the authors estimate that a single placenta may be sufficient to produce over 7,000 doses of therapeutic MSC using a large scale process.

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