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K. Youssef, J.J. Mack, M.L. Iruela-Arispe and L.-S. Bouchard Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor Biotechnology and Bioengineering 109

Version of Record online: 23 JAN 2012 | DOI: 10.1002/bit.24440

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A versatile approach to controlling internal shear stress in porous scaffold bioreactors is presented based on topology optimization. Micro-channels are patterned in the scaffold to yield a target shear stress distribution. Unlike conventional methods to optimize material microstructure by changing the chemical composition, the new method could yield arbitrary spatial distributions. For example, the target distribution can be uniform or could include gradients. The systematic optimization of the distribution will enable the design of improved cell culture protocols.

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