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Suresh Selvarasu, Ying Swan Ho, William P. K. Chong, Niki S. C. Wong, Faraaz N. K. Yusufi, Yih Yean Lee, Miranda G. S. Yap and Dong-Yup Lee Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture Biotechnology and Bioengineering 109

Version of Record online: 31 JAN 2012 | DOI: 10.1002/bit.24445

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The current study exploited a combined metabolomics and in silico modeling approach to characterize the cellular mechanisms of Chinese hamster ovary (CHO) fed-batch cultures. The results identified major growth-limiting factors including the oxidative stress and depletion of lipid metabolites. Such key information on growth-related mechanisms derived from the current approach can potentially guide the development of new strategies to enhance CHO culture performance.

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