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Nihal Engin Vrana, Agnes Dupret-Bories, Charlotte Bach, Christophe Chaubaroux, Christelle Coraux, Dominique Vautier, Fouzia Boulmedais, Youssef Haikel, Christian Debry, Marie-Helene Metz-Boutigue and Philippe Lavalle Modification of macroporous titanium tracheal implants with biodegradable structures: Tracking in vivo integration for determination of optimal in situ epithelialization conditions Biotechnology and Bioengineering 109

Version of Record online: 2 MAR 2012 | DOI: 10.1002/bit.24456

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Hierarchically porous PLLA/titanium scaffolds which can direct cell movement in vitro were shown to control cell movement in vivo and also in a tracheal replacement model. Methods based on protein characterization were utilized to determine the optimal time point for in situ epithelialization together with development of a basement membrane-like collagen/alginate multilayer structure to improve epithelialization. The monitoring of implant integration with protein characterization and improvement of epithelialization of porous titanium implants would improve their patency in tracheal replacement.

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