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P. Moisset, D. Vaisman, A. Cintolesi, J. Urrutia, I. Rapaport, B.A. Andrews and J.A. Asenjo Continuous modeling of metabolic networks with gene regulation in yeast and in vivo determination of rate parameters Biotechnology and Bioengineering 109

Version of Record online: 24 APR 2012 | DOI: 10.1002/bit.24503

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A continuous model of a metabolic network and gene regulation in yeast using glucose and ethanol was compared with experimental data. The model is constructed using enzyme kinetics, the mechanisms of gene expression and enzyme synthesis, and data from microarrays. Data from metabolic flux analysis (MFA) is used to fit the equation parameters. The proposed method allows the obtention of reasonable parameters and concentrations in a system with a much larger number of unknowns (120) than equations (72).

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