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Ryan J. McCoy and Fergal J. O'Brien Visualizing feasible operating ranges within tissue engineering systems using a “windows of operation” approach: A perfusion-scaffold bioreactor case study Biotechnology and Bioengineering 109

Article first published online: 11 JUN 2012 | DOI: 10.1002/bit.24566

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This work introduces the tissue engineering community to a graphical visualization tool called “Windows of Operation”. This tool allows users to set pre-defined constraint levels for the required performance specification of their system (e.g. cell detachment <20% (blue) or fold change in gene expression >45 (green)) based on different operating conditions (e.g. mean pore size and mean shear stress) and determine whether feasible operating ranges exist that allow the constraints to be met simultaneously (purple).

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