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Giovanni G. Giobbe, Monica Zagallo, Massimo Riello, Elena Serena, Giulia Masi, Luisa Barzon, Barbara Di Camillo and Nicola Elvassore Confined 3D microenvironment regulates early differentiation in human pluripotent stem cells Biotechnology and Bioengineering 109

Version of Record online: 20 JUN 2012 | DOI: 10.1002/bit.24571

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In the present work, Giobbe and coworkers aimed to study the effect of different confined three-dimensional microenvironments on early differentiation of the three germ layers, in embryoid bodies derived from human embryonic stem cells and human induced pluripotent stem cells. In both cell lines, the local accumulation of soluble secreted factors, given by specific microwell design in a permeable biomaterial, induces defined differentiation patterns.

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